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Is Your
Depressed Patient Bipolar? (original text)
- Is your Depressed Patient Bipolar
(June 2005, with charts and revisions)
Abstract: Accurate diagnosis of mood disorders is
critical to their effective treatment. Distinguishing
between major depression and bipolar disorders, especially the
depressed phase of a bipolar
disorder, is essential, since they differ substantially in their
genetics, clinical course, outcomes, prognosis, and treatment. In
current practice, bipolar disorders, especially bipolar II disorder,
are underdiagnosed. Misdiagnosing bipolar disorders deprives
patients of timely and potentially lifesaving treatment,
particularly considering the development of newer and possibly more
effective medications for both depressive features and the
maintenance treatment (prevention of
recurrence/relapse). This article focuses specifically on how to
recognize the identifying features suggestive of a bipolar disorder
in patients who present with depressive symptoms or who have
previously been diagnosed with major depression or dysthymia. This
task is not especially time-consuming, and the interested primary
care or family physician can easily perform this assessment. Tools
to assist the physician in daily practice with the evaluation and
recognition of bipolar disorders and bipolar depression are
presented and discussed.
Key Words:
bipolar
disorders, bipolar II, depression, bipolar depression
A Primary
Care Approach to Bipolar Disorder
Many patients with bipolar disorder can be successfully managed in
primary care if the physician uses the tools and information
available. Bipolar disorder treatment encompasses far more than
pharmacotherapy. Non-pharmacologic interventions are vital. Numerous
medications are effective in treating this disorder but they do not
exhibit class effects. Anticonvulsants and antipsychotic drugs, in
particular, have very different efficacy and safety profiles. This
article discusses the types of non-pharmacologic therapies that have
shown success in bipolar disorder management, pharmacotherapy goals
and options, clinical pearls for using atypical antipsychotics in
bipolar disorder (including off-label usage), and medical
comorbidities as potential treatment confounders (namely obesity and
diabetes). With messages of hope, direction, and the importance of
adherence, PCPs can have a dramatic impact on the outcomes of their
patients with bipolar disorder.
Families,
Murder, and Insanity: A Psychiatric Review of Paternal Neonaticide
Abstract: Neonaticide
is the killing of a newborn within the first 24 hours of life. Although
relatively uncommon, numerous cases of maternal neonaticide have been
reported. To date, only two cases of paternal neonaticide have appeared
in the literature. The authors review neonaticide and present two new
case reports of paternal neonaticide. A psychodynamic explanation of
paternal neonaticide is formulated. A new definition for neonaticide,
more consistent with biological and psychological determinants is
suggested.
When
Your Patient Commits Suicide
The Psychiatrist's Role, Responses, and Responsibilities
Abstract: Suicides
constitute a not infrequent event in a psychiatrist's practice and have a
major impact upon the clinician as well as the family and the staff. Many
psychiatrists especially those in residency are never taught how to manage
a patient's suicide. The authors share their experiences in this area and
make clear recommendations for interventions with staff, family, and other
patients. Careful attention to the physician's own needs are suggested. It
is suggested that this material be made part of psychiatry residents
training.
Feigned Insanity in
Nineteenth Century America Legal Cases
Abstract: Today, it is
only out of necessity that lawyers bring physicians into the courtroom.
Indeed, it is only the ability of an expert witness to give opinion
testimony and to answer hypothetical questions that makes his attendance
attractive to the bar at all. In reviewing the cases of feigned insanity
during the 1800's it becomes clear that the same sentiments existed then
as well. Indeed, little has changed during the intervening century.
The
Pharmacological Treatment of Sexual Offenders
Abstract: As
a result of the Kansas v Hendricks decision in the US Supreme Court,
upholding the civil committal of sexual offenders under sexual predator
statutes, the treatment of sexual deviation has become a focus of
considerable national interest. The effective treatment of sexual
deviants is a complicated issue that involves psychological and
pharmacological treatment approaches. Psychiatrists because of their
training in medicine and skills in psychotherapy should be ideally
suited to treat these individuals as there is general agreement among
experts that a combined psychological and pharmacological treatment
approach is most effective. Biological treatments,
specifically surgical castration and stereotaxic neurosurgery have been
used historically in the treatment of sexual offenders to reduce
their sexual drive and to prevent recidivism.
LaLonde
v. Eissner
Massachusetts Protects Court Appointed Expert Witnesses
Abstract: Previously, I have
reported on two important cases involving the relationship of the
judiciary and expert witnesses. In Tolisano v Texon, the New York State
Court of Appeals, the State's highest court, ruled that there existed no
doctor-patient relationship when a forensic evaluation is performed.
In so doing, the court acted to protect expert witnesses and finally
reaffirmed a concept which experts have consistently maintained. In
McNamara v. Honeyman the Massachusetts Supreme Judicial Court, that
State's highest court, ruled that if a physician defendant was a public
employee then he/she would be protected from not only negligence but from
gross negligence as well.
I am pleased to add the case
of LaLonde v. Eissner to this growing list of case law which helps to
articulate the role of a forensic psychiatrist and the protection's to be
afforded in the conduct of our work. This may be the first time a State's
highest court has granted judicial immunity to a forensic psychiatrist
performing an evaluation in the absence of a specific court order for the
evaluation.
Tolisano
v Texon:
New York States Protects Expert Witnesses
Abstract: Every expert
witness is familiar with the four D's of tort law: a Dereliction of a Duty
Directly causing Damages. In order for a tort claim to be successful all
four of these elements must be proven. The professions, medicine in
particular, have long held that when examining and rendering an opinion
for a third party, no malpractice could be charged as clearly there was no
patient/physician relationship and hence no Duty to the individual.
This reasoning allows for
participation by psychiatrists in insurance examinations, competency
hearings and a host of other forensic examinations. Although this
reasoning may seem clear to A.A.P.L. members, until the New York State
Court of Appeals (the State's highest court) overturned a New York
State Supreme Court Appellate Division ruling this issue was in doubt.
American Psychiatric Publishing Inc.
0895-0172 EN RC4867 Letters
An Open Label Trial of Donepezil (Aricept) in the
Treatment of Persons with Mild Traumatic Brain Injury.
We read with interest, the review
by Griffin et. al.1 on the use of cholinergic agents in the
treatment of persons who sustained traumatic brain injury (TBI). As
early as 1997 (Poster session at the joint meeting of the American
Neuropsychiatric Association and the British Neuropsychiatry
Association. Cambridge, England.), we too suspected that these
medications might be beneficial in treating cognitive dysfunction,
memory deficits, and emotional instability, all observed in TBI.
Psychic Akathisia
Use of atypical antipsychotics has become the standard of care in
the treatment of psychosis. As newer agents enter the marketplace,
clinicians have a choice of medications with significantly different
receptor binding profiles. Ziprasidone, the newest agent on the
market, is notable for its ability to act as a 5HT1-A agonist. In
addition, ziprasidone is thought to bind almost exclusively in the
A10 mesolimbic/mesocortical pathway and to avoid the A9
nigrostriatal pathway in the brain. Thus, akathisia would not be
expected to be a frequent occurrence with this medication.
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www.currentpsychiatry.com
Challenges in
Recognition, Clinical Management, and Treatment of Bipolar Disorders
at the Interface of Psychiatric Medicine and Primary Care
-
Defining the challenge: Recognizing and treating bipolar disorders
wherever
patients present
-
Challenges in diagnosing bipolar disorder: Identifying Mixed
Episodes . . . . . . . . . . .
-
Clinical management of bipolar disorder: Achieving best outcomes
through a Role of the primary care provider
-
Treatment by phase: Pharmacologic management of bipolar disorder
-
Recognizing bipolar disorder on initial presentation: A case study
with decision points

www.jfponline.com
Challenges in Recognition, Clinical Management, and Treatment of
Bipolar Disorders at the Interface of Psychiatric Medicine and
Primary Care
- Defining the challenge: Recognizing and treating bipolar disorders
wherever patients present
- Challenges in diagnosing bipolar disorder: Identifying Mixed
Episodes
- Clinical management of bipolar disorder: Achieving best outcomes
through a Role of the primary care provider.
- Treatment by phase: Pharmacologic management of bipolar disorder
- Recognizing bipolar disorder on initial presentation: A case study
with decision points
Effect of Open-Label Lamotrigine
as Monotherapy
and Adjunctive Therapy on the Self-Assessed Cognitive
(August 2007)
Abstract: Cognitive deficits in patients with bipolar disorder are
likely to impair occupational and social functioning. In a post hoc
analysis of data from a prospective, open-label study of lamotrigine
in 1175 patients 13 years or older with bipolar I disorder, changes
in the self-rated cognitive function scores of patients receiving
lamotrigine as monotherapy or as adjunctive therapy were evaluated.
Lamotrigine was given for 12 weeks, with a target dosage of 200
mg/d.
Alleged Sexual Abuse
in the Context of Divorce
Abstract: Alleged sexual
abuse looms as one of the most difficult, controversial and challenging
issues facing society. In almost all cases, it is one person's word
against another's in a crime that is not witnessed. Assuming we have a
special ability to discern truth, society often calls upon psychiatrists
to either substantiate or to invalidate such a claim. This task is
complicated enough in the course of normal therapy and without the threat
of litigation. In the context of divorce, the allegation by one party that
a child has been abused poses a question that would cross Solomon's eyes.
Sexual
Deviancy
Abstract: Sexual deviancy is a rather broad and vague term. Its usage
connotes that there are recognized norms of sexual behavior which are
accepted by society in general. In fact, "normal" sexual
behavior has never been well categorized. Rather, aberrant behaviors,
sufficiently unacceptable to most persons, have been lumped together to
comprise sexual deviancy. These of course may vary over time and across
different cultures, although there are probably some behaviors which
almost everyone would label deviant.
Tardive
Dyskinesia: Tremors in Law and Medicine
Abstract: Although debate exists as to the incidence and prevalence of antipsychotic induced tardive dyskinesia (TD), it is readily accepted that antipsychotics can and often do induce this potentially irreversible movement disorder. Prevalence rates of 25%-40% and incidence rates of 1-3% annually are commonly reported. Ongoing and controversial research shows tardive dyskinesia may in fact be part of the normal aging process occurring in up to 32% of persons
never exposed to an antipsychotic. Despite this, if a person has ever been exposed to an antipsychotic and later develops TD, the chance that the drug will be blamed is high. In this article, I review the various legal theories that may be invoked in a case involving TD, including relevant case law to illustrate each of the theories. This is the first article published in a peer reviewed scientific journal to suggest that all patients should be offered the opportunity to try the newer "atypical" antipsychotics which may be much safer agents.
Rand v. Miller:
Can Record Review Constitute a Doctor-Patient Relationship?
Abstract: In 1987, A.A.P.L.
issued Ethical Guidelines for the Practice of Forensic Psychiatry. These
were revised in 1989 and again in 1991. One of the most generally held
concepts is the need to examine an individual, if at all possible, prior
to rendering an opinion as to their psychiatric condition, if any. This
stems from the controversial "Goldwater Rule" issued by the
A.P.A. Nonetheless, there are circumstances where physicians,
psychiatrists and even forensic psychiatrists continue to, on a regular
basis, issue written opinions without even the slightest of efforts to
interview the individual in question.
Recently, in Rand v. Miller, the Supreme Court of West Virginia shared
with us its opinion on this pressing issue. It is one of a series of
cases on which I have reported which deal with the relationship between a
forensic psychiatrist and an evaluee. Clearly, the Miller case
continues the trend of decisions affirming the lack of a doctor patient
relationship in a forensic setting.
State v. Szemple:
Marital-Communication and the Priest-Penitent Privilege
Abstract: On May 12, 1994,
the Supreme Court of New Jersey handed down one of the most interesting
decisions of the decade. In daring to tread where few have had the
courage, the court addressed the confidential relationship between a
priest and a penitent and in so doing, has changed the thinking of at
least the last 500 years. In addition, an important ruling on the
marital-communication privilege was made.
McNamara
v. Honeyman:
Massachusetts Protects Psychiatrist
Abstract: One of the greatest
problems encountered by State Hospitals is the difficulty they have
attracting well-trained psychiatrists to work with the chronically
mentally ill. In particular, the potential liability that attends to
working with this population has been a concern of many. Until Honeyman,
the leading case in Massachusetts was Florio v. Kennedy. Florio held
that if a physician were a "public employee" he/she would be
held immune from liability under the Tort Claims Act
In Honeyman, the court went well beyond the Florio standard and indeed may
now be on the cutting edge in this regard. Here, the Supreme Judicial
Court (Massachusetts's highest court) ruled that "For purposes of the
Massachusetts Tort Claims Act, it is not material whether the conduct of
an employee constitutes gross negligence or merely simply negligence.
The Journal of Clinical Psychiatry
Ziprasidone
augmentation of clozapine
Clozapine, the oldest atypical antipsychotic remains the "gold standard"
in the treatment of Schizophrenia and associated psychotic disorders (1).
However, the side effects of this treatment are well known and include
significant weight gain and an anticholinergic profile (2). The concept of
adding quetiapine to clozapine with the potential to lower the dose of
clozapine, and thus reduce the side effect profile of the clozapine has
been supported clinically and in the literature (3,4).
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